Shengyuan Wang, PhD
School of Systems Biology
George Mason University
Manassas, VA 20110
Shengyuan Wang, PhD
Department of Bioinformatics and Computational Biology
School of Systems Biology
George Mason University
10900 University Blvd
Manassas, VA 20110
EDUCATION
2016 - 2022 Ph.D., Bioinformatics and Computational Biology, George Mason University (GMU). GPA: 3.97/4.00
Dissertation: Structural and Topological Variations in Amino Acids Encoded by Synonymous Codons
2014 - 2016 M.S., Pharmaceutical Science, North Carolina Central University (NCCU). Summa Cum Laude, GPA: 3.93/4.00
Thesis: Investigation of Polymer-Functionalized Carbon Nanotube-Coated Filters for Removal of Bacteria
2009 - 2013 B.S., Biotechnology, China Agricultural University (CAU).
Thesis: Method Improvement of Transformation of Shuttle Plasmids into Paenibacillus massiliense T7
RESEARCH EXPERIENCE
2016 - 2021 Graduate Research Assistant, School of Systems Biology, Department of Bioinformatics and Computational Biology, GMU
- Build a dataset containing 10,220 individual proteins capturing sequences and structural information from BLAST and PDB, serving as the major database for dissertation research
- Design and investigate the relationship between protein structure and topological variations in amino acid residues encoded by synonymous codons using knowledge-based potentials
- Analyze the association between abnormal protein secondary structures and protein biological functions using machine learning
- Develop models to predict protein fitness for all single residue mutants of beta-lactamases proteins using machine learning algorithms
- Investigate the mechanism of Ibuprofen’s block effect on the aggregation process of A-beta peptide in Alzheimer’s disease with molecular modeling, summarizing results in a report
- Analyze transcriptome to compare gene expression patterns in human fetal and adults using R
- Proficient in large and complex biological data curation, analysis, and statistical testing in Python (5 years of experience)
- Mentor junior colleagues on bioinformatic analysis methods and statistical analysis
2014 - 2016 Graduate Research Assistant, Biomanufacturing Research Institute and Technology Enterprise (BRITE), NCCU
- Solid course training in Drug discovery, Pharmacology, Immunology, Biochemistry, Biopharmaceutical manufacturing, and Cloning and expression
- Completed a project to construct pharmacophore models for virtual screening of estrogen receptor in MOE, selected as the best project among a total of 20 graduate students
- Knowledge of drug discovery of small and large molecule therapeutics, drug research & development, and FDA regulations
- Designed and conducted experiments to investigate the bacteria removal effect of polymer-functionalized carbon nanotube-coated filters, produced one first-authored publication
- Collaborated with colleagues in study design and implementation, data analysis and results interpretation, produced two co-authored publications
2012 - 2013 Undergraduate Research Assistant, China Agricultural University
- Optimized the method for transformation of shuttle plasmids into Paenibacillus massiliensis T7
HONORS AND REWARDS
2016 - 2021 Presidential Scholarship Recipient, GMU
2021 Outstanding Oral Presentation, GMU
2019 Graduate Student Outreach Award, GMU
2016 First Place Poster Presentation in Graduate Research Symposium, NCCU
2015 Outstanding Graduate Research in Pharmaceutical Sciences, NCCU
2014 - 2016 Graduate Research Scholarship, NCCU
CONFERENCE PRESENTATION
2021 Analysis of topological properties of cancer-causing synonymous mutations, Poster Presentation, Frontiers of Computing in Health and Society, GMU, virtually
2021 ValgusHel: A novel method to identify and characterize kinked alpha-helices, Poster Presentation, The Protein Society – 35th Anniversary Symposium, virtually
2019 Structural and topological variations in amino acid residues encoded by synonymous codons, Poster Presentation, AAAS Annual Meeting, Washington, D.C.
2016 Investigation of polymer-functionalized carbon nanotube-coated filters for removal of bacterial pathogens, Poster Presentation, IBE Annual Conference, Greenville, South Carolina
2016 Poster Presentation, NCCU Research Symposium
2015 Oral Presentation, NCCU Research Symposium
PUBLICATIONS
- Al Awak, M. M., Wang, P., Wang, S., Tang, Y., Sun, Y. P., & Yang, L. (2017). Correlation of carbon dots' light-activated antimicrobial activities and fluorescence quantum yield. RSC advances, 7(48), 30177-30184.
- Meziani, M. J., Dong, X., Zhu, L., Jones, L. P., LeCroy, G. E., Yang, F., Wang, S., ... & Tripp, R. A. (2016). Visible-light-activated bactericidal functions of carbon “Quantum” dots. ACS applied materials & interfaces, 8(17), 10761-10766.
- Wang, S., LeCroy, G. E., Yang, F., Dong, X., Sun, Y. P., & Yang, L. (2015). Carbon nanotube-assisted capturing of bacterial pathogens. RSC Advances, 5(111), 91246-91253.
CERTIFICATES
VOLUNTEER EXPERIENCE
2021 Student mentor, Aspiring Scientists Summer Internship Program (ASSIP), GMU
2019 Student mentor, ISCB Youth Bioinformatics Symposium
COURSES
- Bioinformatics core courses: Protein Structure Analysis, Biological Programming in Perl, Biological Data Analysis in R, Biological Sequence Analysis, Biomolecular Modeling, Biophysics, Systems Biology, Numerical Methods, and Cheminformatics.
- Pharmaceutical sciences core courses: Drug discovery, Biopharmaceutical manufacturing, Pharmacology, Immunology, Cloning and expression, and Biochemistry,
TECHNICAL SKILLS
- Interest Areas: Protein Structure and Function Analysis, Next Generation Sequencing, Molecular Modeling, Machine Learning
- Programming/Markup Languages: Python, R, Perl, Bash, Git, SQL, Octave, Html, Markdown
- NGS tools: Bioconductor, Galaxy, Samtools/BCFtools/Bedtools/Bowtie2/Tophat/Cufflinks
LANGUAGES
English, Mandarin
REFERENCE
Dr. Iosif Vaisman, Professor, School of Systems Biology, GMU (Dissertation Mentor)
E-mail: ivaisman@gmu.edu
Dr. Liju Yang, Professor, Department of Pharmaceutical Sciences, NCCU (Thesis Mentor)
E-mail: lyang@nccu.edu
