Christopher Lockhart, Ph.D.

Bioinformatics and Computational Biology
School of Systems Biology

George Mason University
10900 University Boulevard, MS 5B3
Manassas, VA 20110

Contact:
Phone: (703) 993-4459
Email: clockha2@gmu.edu (preferred)
Website: http://binf.gmu.edu/clockha2/


Education:
George Mason University, Manassas, VA, August 2010-December 2015
Ph.D., Bioinformatics and Computational Biology

Virginia Polytechnic Institute and State University, Blacksburg, VA, August 2006-May 2010
B.S., Biological Sciences
B.S., Psychology
Minor, Chemistry


Research Experience:
Laboratory of Biomolecular Simulations, George Mason University, January 2011-Present
P.I.: Prof. Dmitri Klimov


Teaching Experience:
Modeling and Simulation I (CDS-230), George Mason University, Fall 2017
Adjunct Instructor

Computing for Scientists (CDS-130), George Mason University, Spring 2016 & Spring 2017
Adjunct Instructor

Systems Biology (BINF-701/BIOS-701), George Mason University, Fall 2016
Adjunct Instructor


Other Work Experience:
Information Management Consultants, Inc, Reston, VA, February 2011-August 2012
User Support/Analyst

XO Communications, LLC, Herndon, VA, May 2009-August 2009
Human Resources Management Systems Coordinator Intern


Awards:
  1. Outstanding Doctoral Student Award, School of Systems Biology, George Mason University, May 11, 2016
  2. Impact Award, School of Systems Biology, George Mason University, May 15, 2013
  3. Student Research Day Outstanding Oral Presentation, School of Systems Biology, George Mason University, December 4, 2012
  4. Bioinformatics and Computational Biology Award for Outstanding Research Achievement in the Course of Doctoral Studies, School of Systems Biology, George Mason University, May 16, 2012
  5. Navachat Tongvichit Bioinformatics Memorial Award, School of Systems Biology, George Mason Univeristy, May 19, 2011

Reviewing Activites:
  • Journal of Physical Chemistry B

Research Presentations:
  1. Probing the binding of Aβ peptides to lipid bilayers. Biophysical Society 61st Annual Meeting. Ernest N. Morial Convention Center, New Orleans, LA. February 14, 2017.
  2. Binding of Aβ monomer to DMPC bilayer using isobaric-isothermal replica exchange molecular dynamics. Biophysical Society 59th Annual Meeting. Baltimore Convention Center, Baltimore, MD. February 8, 2015.
  3. Binding of Aβ monomer to DMPC bilayer using isobaric-isothermal replica exchange molecular dynamics. Student Research Day. School of Systems Biology, George Mason University, Manassas, VA. December 2, 2014.
  4. Binding of FDDNP biomarker to Alzheimer's disease Aβ peptide. Biophysical Society 57th Annual Meeting. Philadelphia Convention Center, Philadelphia, PA. February 5, 2013.
  5. Binding of FDDNP biomarker to Alzheimer's disease Aβ peptide. Student Research Day. School of Systems Biology, George Mason University, Manassas, VA. December 4, 2012. (Won award for outstanding oral presentation).

Invited Talks:
  1. Molecular dynamics simulations of peptides relevant to Alzheimer's disease. Colloquia of Computational Materials Science Center. George Mason University, Fairfax, VA. October 26, 2015.

Published Abstracts:
  1. Lockhart, C. & Klimov, D. K. (2017) Probing the binding of Aβ peptides to lipid bilayers. Biophys. J. 112(3): 364a, doi:10.1016/j.bpj.2016.11.1973
  2. Lockhart, C. & Klimov, D. K. (2015) Binding of Aβ monomer to DMPC bilayer using isobaric-isothermal replica exchange molecular dynamics. Biophys. J. 108(2): 64a-65a, doi:10.1016/j.bpj.2014.11.386
  3. Lockhart, C. & Klimov, D. K. (2013) Binding of FDDNP biomarker to Alzheimer's disease Aβ peptide. Biophys. J. 104(2): 360a, doi:10.1016/j.bpj.2012.11.2000

Publications:
  1. Lockhart, C., Smith, A. K., & Klimov, D. K. (2019) Methionine oxidation changes the mechanism of Aβ peptide binding to the DMPC bilayer. Sci. Rep. 9(5947): 1-12, doi:10.1038/s41598-019-42304-9
  2. Lockhart, C. & Klimov, D. K. (2017) Cholesterol changes the mechanism of Aβ peptide binding to the DMPC bilayer. J. Chem. Inf. Model. 57(10): 2554-2565, doi:10.1021/acs.jcim.7b00431
  3. Siwy, C. M., Lockhart, C., & Klimov, D. K. (2017) Is the conformational ensemble of Alzheimer's Aβ10-40 peptide force field dependent? PLoS Comput. Biol. 13(1): e1005314, doi:10.1371/journal.pcbi.1005314
  4. Smith, A. K., Lockhart, C., & Klimov, D. K. (2016) Does replica exchange with solute tempering efficiently sample Aβ peptide conformational ensembles? J. Chem. Theory Comput. 12(10): 5201-5214, doi:10.1021/acs.jctc.6b00660
  5. Lockhart, C. & Klimov, D. K. (2016) The Alzheimer's disease Aβ peptide binds to the anionic DMPS lipid bilayer. Biochim. Biophys. Acta 1858(6): 1118-1128, doi:10.1016/j.bbamem.2016.03.001
  6. Lockhart, C., O'Connor, J., Armentrout, S., & Klimov, D. K. (2015) Greedy replica exchange algorithm for heterogeneous computing grids. J. Mol. Model. 21(9): 243, doi:10.1007/s00894-015-2763-5
  7. Lockhart, C. & Klimov, D. K. (2015) Calcium enhances binding of Aβ monomer to DMPC bilayer. Biophys. J. 108(7): 1807-1818, doi:10.1016/j.bpj.2015.03.001
  8. Lockhart, C. & Klimov, D. K. (2014) Binding of Aβ peptide creates lipid density depression in DMPC bilayer. Biochim. Biophys. Acta 1838(10): 2678-2688, doi:10.1016/j.bbamem.2014.07.010
  9. Lockhart, C. & Klimov, D. K. (2014) Alzheimer's Aβ10-40 peptide binds and penetrates DMPC bilayer: an isobaric-isothermal replica exchange molecular dynamics study. J. Phys. Chem. B 118(10): 2638-2648, doi:10.1021/jp412153s
  10. Lockhart, C. & Klimov, D. K. (2013) Revealing hidden helix propensity in Aβ peptide by molecular dynamics simulations. J. Phys. Chem. B 117(40): 12030-12038, doi:10.1021/jp407705j
  11. Lockhart, C. & Klimov, D. K. (2012) Molecular interactions of Alzheimer's biomarker FDDNP with Aβ peptide. Biophys. J. 103(11): 2341-2351, doi:10.1016/j.bpj.2012.10.003
  12. Lockhart, C., Kim, S., & Klimov, D. K. (2012) Explicit solvent molecular dynamics simulations of Aβ peptide interacting with ibuprofen ligands. J. Phys. Chem. B 116(43): 12922-12932, doi:10.1021/jp306208n
  13. Lockhart, C., Kim, S., Kumar, R., & Klimov, D. K. (2011) Does amino acid sequence determine the properties of Aβ dimer? J. Chem. Phys. 135: 035103, doi:10.1063/1.3610427


Je parle aussi un peu le français.



PubMed ORCID Google Scholar ResearchGate LinkedIn

© 2017 Christopher Lockhart