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Christopher Lockhart, Ph.D.
Postdoctoral Research Fellow
School of Systems Biology
George Mason University
Manassas, Virginia
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Systems Biology (Fall 2016)
BINF 701/BIOS 701
Syllabus
Wednesdays, 1:30-4:10 PM
327 Occoquan Building, SciTech Campus
August 31 through December 14
Instructor: Dr. Christopher Lockhart, 703-993-4459, clockha2@gmu.edu (preferred)
Office: 328C Occoquan Building, SciTech Campus
Office Hours: By appointment
Course Description
Systems biology seeks to understand how complex biological systems function.
This involves the use of computational methods and models to integrate information obtained about these systems through a wide range of methods spanning multiple spatial and temporal scales.
Current research examples will be used to motivate and demonstrate these approaches.
This is a 3-credit course.
Prerequisites
Admission to PhD program in biosciences or bioinformatics; CHEM 663 or equivalent.
Textbook
This course will use the textbook “A First Course in Systems Biology” written by Eberhard O. Voit and published by Garland Science (ISBN: 978-0-8153-4467-4).
You can find this book at the GMU bookstore or on Amazon.com.
Lecture material will be based heavily on this textbook.
Grading Policy
Student grades will be assessed through a midterm project (worth 30% of the total grade), a final project (worth 30%), and a final exam (worth 40%).
Final grades will be determined from the scale below:
| A+ | 98-100% |
| A | 90-97% |
| B+ | 87-89% |
| B | 80-86% |
| C+ | 77-79% |
| C | 70-76% |
| D | 60-69% |
| F | ≤59% |
Students are expected to attend all lectures and participate in class discussions.
Class Announcements
Any pertinent class announcements will generally be sent to your GMU email accounts.
The most current lecture content (including PowerPoint presentations) will be posted to the class Blackboard page.
Academic Honesty Policy
This course adheres to the Mason honor code, which states that students must not cheat, plagiarize, steal, or lie in matters related to their academic work.
Please ensure that all work you submit is original and contains proper attribution.
If you have any doubts about what constitutes as plagiarism, please contact me.
Disabilities
If you have a documented learning disability or other condition that may affect academic performance you should: (1) make sure this documentation is on file with Office of Disability Services (SUB I, Rm. 4205; 703-993-2474; http://ods.gmu.edu) to determine the accommodations you need, and (2) talk with me to discuss your accommodation needs.
Schedule
The tentative schedule for the semester is detailed below.
Note that this is subject to change.
Please contact me as soon as possible if you are unable to attend any important dates (marked by *).
| August 31 | Introduction to Systems Biology |
| September 7 | Introduction to Mathematical Modeling |
| September 14 | Static Network Models |
| September 21 | The Mathematics of Biological Systems |
| September 28 | Parameter Estimation |
| October 5 | Midterm Presentations* |
| October 12 | Midterm Presentations* |
| October 19 | Gene Systems |
| October 26 | Protein Systems |
| November 2 | Metabolic Systems |
| November 9 | Signaling Systems |
| November 16 | Population Systems |
| November 23 | Thanksgiving Recess |
| November 30 | Final Presentations* |
| December 7 | Final Presentations* |
| December 14 | Final Exam* |
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