AUTOMUTE

AUTO
mated server for predicting...
      ...functional consequences of amino acid MUTations in protEins

tessellated_t4_lysozyme

 

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Stability Changes (ΔΔG)


Stability Changes (ΔΔGH2O)

Stability Changes (ΔTm)

Activity Changes

Disease Potential of Human nsSNPs

Structural Bioinformatics at
George Mason University

Questions or Comments?
mmasso@gmu.edu

Stability Changes (ΔΔGH2O)


PDB ID
(e.g., 3PHV)

Chain
(use @ if null)

Mutation
(e.g., D25E)

Temperature
(ºC, 0-100)

pH
(-log[H+], 0-14)

Mutant #1

Mutant #2

Mutant #3

Mutant #4

Mutant #5

Note: Use D25_ to obtain predictions for all 19 substitutions at the requested position.

Select a model for making predictions (details):

Classification (sign of ΔΔG_H2O):
 Regression (value of ΔΔG
_H2O):

Random Forest
Tree Regression (REPTree)

Support Vector Machine (SVM)
SVM Regression