AUTO–MUTE AUTOmated server for predicting... ...functional consequences of amino acid MUTations in protEins
AUTO-MUTE Home Stability Changes (ΔΔG)
Stability Changes (ΔΔGH2O)
Stability Changes (ΔTm) Activity Changes Disease Potential of Human nsSNPs Structural Bioinformatics at George Mason University Questions or Comments? mmasso@gmu.edu
PDB ID (e.g., 3PHV)
Chain (use @ if null)
Mutation (e.g., D25E)
Temperature (ºC, 0-100)
pH (-log[H+], 0-14)
Mutant #1
Mutant #2
Mutant #3
Mutant #4
Mutant #5
Note: Use D25_ to obtain predictions for all 19 substitutions at the requested position. Select a model for making predictions (details):
Classification (sign of ΔΔG_H2O): Regression (value of ΔΔG_H2O):
Random Forest Tree Regression (REPTree)
Support Vector Machine (SVM) SVM Regression