AUTO–MUTE AUTOmated server for predicting... ...functional consequences of amino acid MUTations in protEins
AUTO-MUTE Home Stability Changes (ΔΔG) Stability Changes (ΔΔGH2O)
Stability Changes (ΔTm)
Activity Changes Disease Potential of Human nsSNPs Structural Bioinformatics at George Mason University Questions or Comments? mmasso@gmu.edu
PDB ID (e.g., 3PHV)
Chain (use @ if null)
Mutation (e.g., D25E)
Mutant #1
Mutant #2
Mutant #3
Mutant #4
Mutant #5
Note: Use D25_ to obtain predictions for all 19 substitutions at the requested position. Select a model for making predictions (details):
Classification (sign of ΔTm): Regression (value of ΔTm):
AdaBoostM1/C4.5 Tree Regression (REPTree)
Support Vector Machine (SVM) SVM Regression