A manually curated database of all the unique mutations for the top 15 mutated genes in NSCLC

Gene Gene Mutation Frequency COSMIC ID AA Mutation Type of Mutation Frequency of Unique Mutation (%) Drug Resistance Drug Sensitivity 
EGFR 25% COSM12979 p.L858R Substitution - Missense 0.0686 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM13243 p.?del Deletion - In frame 6.1082 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM12980 p.E746_A750del Deletion - In frame 3.0723 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM6224 p.L858R Subsitituion-Missense  2.5148 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM6223 p.E746_A750delELREA Deletion - In frame 1.5876 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM21943 p.T790M  Substitution - Missense 0.8787 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM13173 p.L861Q Substitution - Missense 0.2727 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM13564 p.L747_P753>S Complex - deletion inframe 0.2121 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM13448 p.G719A Substitution - Missense 0.1212 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM6240 p.T790M Substitution - Missense 0.0909 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM18486 p.S768I Substitution - Missense 0.0879 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM20881 p.G719C  Substitution - Missense 0.0424 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM12384 p.E746_S752>V Complex - deletion inframe  0.0727 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM6213 p.L861Q Substitution - Missense 0.0667 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM26352 p.V769_D770insASV Insertion - In frame 0.0515 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM25873 p.P772_H773insPR  Insertion - In frame  0.0333 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM6252 p.G719S  Substitution - Missense  0.0303 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM18490 p.D770_N771insSVD Insertion - In frame 0.0303 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM12988 c.2125G>A  Substitution  0.0242 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM23623 p.H773R Substitution - Missense 0.0212 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM13424 p.L833V  Substitution - Missense 0.0212 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM12678 p.E746_T751>A Complex - deletion inframe 0.0212 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM28009 p.K745_A750del Deletion - In frame 0.0212 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM18491 p.H773_V774insNPH  Insertion - In frame 0.0212 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM24573 p.L747_T751>P  Complex - deletion inframe  0.0182 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM86965 p.D770>GY Complex - insertion inframe  0.0151 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM28574 p.P848L Substitution - Missense  0.0242 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM27111 p.A871G Substitution - Missense  0.0151 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM30754 p.L747P Substitution - Missense  0.0151 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM12376 p.V769_D770insASV Insertion - In frame 0.0151 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM23571 p.L747_T751delLREAT Deletion - In frame 0.0151 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
EGFR 25% COSM27101 p.L747_E749del Deletion - In frame 0.0151 Afatinib, Erlotinib Afatinib, Erlotinib, Gefitinib, BIBW2992
TP53 25% COSM43617 p.? Substitution - Missense 9.8864 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10660 p.R273H Substitution - Missense 1.6828 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10779 p.R273L Substitution - Missense 0.5469 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10670 p.V157F Substitution - Missense 0.4207 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM96438 p.Y220C Substitution - Missense 0.2945 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM11081 p.G245C Substitution - Missense 0.2945 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM43629 p.R249W Substitution - Missense 0.2524 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM45647 p.I254F Substitution - Missense 0.2524 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10662 p.R248Q Substitution - Missense 0.2524 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM44054 p.L252F Substitution - Missense 0.2524 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10991 p.K132N Substitution - Missense 0.2524 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10808 p.Y163C Substitution - Missense 0.2524 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM6815 p.G154V Substitution - Missense 0.2103 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM6549 p.R248L  Substitution - Missense 0.1683 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10656 p.R248W Substitution - Missense 0.1683 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10817 p.R249S Substitution - Missense 0.1683 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10758 p.Y220C Substitution - Missense 0.1683 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10714 p.R158L Substitution - Missense 0.1262 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10785 p.R249S Substitution - Missense 0.1262 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
TP53 25% COSM10749 p.C277F  Substitution - Missense 0.1262 Nutlin-3a+ Thapsigargin, EpothiloneB, OSU-03012, GNF-2
KRAS 17% COSM516 p.G12C Substitution - Missense 7.3957 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM520 p.G12V Substitution - Missense 4.0905 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM521 p.G12D Substitution - Missense 3.8326 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM522 p.G12A Substitution - Missense 1.2307 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM517 p.G12S Substitution - Missense 0.6095 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM527 p.G13C Substitution - Missense 0.6095 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM532 p.G13D Substitution - Missense 0.504 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM518 p.G12R Substitution - Missense 0.4219 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM14201 p.Q61H Substitution - Missense 0.1641 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM21618 COSM21618 Substitution - Missense 0.1406 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM25877 p.G12D Substitution - Missense 0.1289 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM25878 p.G12C Substitution - Missense  0.1055 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM555 p.Q61H Substitution - Missense  0.0703 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM549 p.Q61K Substitution - Missense 0.0586 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM552 p.Q61R Substitution - Missense 0.0586 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM25881 p.G12A Substitution - Missense 0.0469 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM25879 p.G12V Substitution - Missense 0.0469 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM512 p.G12 Substitution - Missense 0.0469 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM4169642 p.G13C  Substitution - Missense 0.0234 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM18793 p.G13D Substitution - Missense 0.0234 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM1685355 p.G13F Substitution - Missense 0.0234 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM553 p.Q61L Substitution - Missense 0.0234 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM551 p.Q61P Substitution - Missense 0.0117 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM1666976 p.V14L Substitution - Missense 0.0117 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM1666974 p.G13Y Substitution - Missense 0.0117 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM4944035 COSM4944035 Substitution - Missense 0.0117 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM529 p.G13R Substitution - Missense 0.0117 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM25880 p.G12S Substitution - Missense 0.0117 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM550 p.Q61E Substitution - Missense 0.0117 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
KRAS 17% COSM12721 p.G13V Substitution - Missense 0.0117 Vorinostat, NVP-BEZ235, AZD8055, Azitinib, PD-173074, AZD6482, GDC0941, Methotrexate PD-0325901, AZ628, CI-1040, RDEA119, AZD6244, OSI-906, TW37, Z-LLNle-CHO, TFH535, Methotrexate, JNK-9L
ALK 15% COSM4422786 p.L1196M Substitution - Missense  0.8696 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM4422788 p.S1206Y Substitution - Missense 0.8696 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM28498 p.I1171N Substitution - Missense 0.8696 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM97185 p.L1152R Substitution - Missense 0.8696 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM99137 p.L1196M Substitution - Missense 0.8696 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM4422790 p.F1174C Substitution - Missense 0.8696 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM4422791 p.F1174V Substitution - Missense 0.8696 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM99136 p.C1156Y  Substitution - Missense 0.8696 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM4440758 p.I1171S Substitution - Missense 0.8696 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM4422787 p.G1269A Substitution - Missense 1.7391 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM1169707 p.G1269A Substitution - Missense 2.6087 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
ALK 15% COSM4422789 p.G1202R Substitution - Missense 2.6087 17-AAG, ZM447439, p38, JNK2, AZ628, Crizotinib, Seliciclib, GW 441756, Methotrexate, CEP-701, Tretinoin, SB 216763, ABT-263 PD-0332991, JNK Inhibitor VIII, Vinorelbine, Olaparib, Roscovitine
CDKN2A 11% COSM13598 p.? Unknown 3.01 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM12525 p.? Unknown 1.4214 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM12526 p.0? Whole gene deletion 1.1706 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM12524 p.? Unknown 1.087 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM12523 p.? Unknown 0.4181 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM13281 p.E69* Subsititution-Missense  0.3344 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM13587 p.0? Whole gene deletion 0.3344 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM13964 p.Y44* Substitution-Missense 0.2508 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM13489 p.D108Y  Substitution-Missense 0.2508 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM13530 p.? Unknown 0.2508 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM12547 p.W110* Substitution- Nonsense 0.1672 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM12476 p.P114L Substitution-Missense 0.1672 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM12473 p.R58* Substitution- Nonsense 0.1672 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM13567 p.C72* Substitution- Nonsense 0.1672 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
CDKN2A 11% COSM13717 p.E69V Substitution-Missense 0.0836 Cytarabine+, Docetaxel, Midostaurin, Temsirolimus Salubrinal, ABT-263, PAC-1, Nutlin-3a
ATM 7% COSM12793 p.E848Q  Substitution - Missense 2.8571 AZD6738 AZD6738
ATM 7% COSM12791 p.T2666A Substitution - Missense 2.8571 AZD6738 AZD6738
ATM 7% COSM12792 p.L1794L  Substitution - coding silent 2.8571 AZD6738 AZD6738
ATM 7% COSM210743 p.V997fs*1 Unknown 1.4286 AZD6738 AZD6738
ATM 7% COSM210744 p.N429fs*7 Unknown 1.4286 AZD6738 AZD6738
UBR5 5% COSM23129 p.A414T  Substitution - Missense 1.0753 RF-C11 RF-C11
UBR5 5% COSM3269474 p.Q1533* Substitution - Nonsense 1.0753 RF-C11 RF-C11
UBR5 5% COSM23126 p.V968I Substitution - Missense 1.0753 RF-C11 RF-C11
UBR5 5% COSM26913 p.A870S Substitution - Missense 1.0753 RF-C11 RF-C11
UBR5 5% COSM25327 p.F2023F Substitution - coding silent 1.0753 RF-C11 RF-C11
CBL 4% COSM41272 p.V391I Substitution - Missense 1.0638 Erlotinib Erlotinib
CBL 4% COSM41274 p.A848T  Substitution - Missense 0.5319 Erlotinib Erlotinib
CBL 4% COSM41270 p.H94Y Substitution - Missense 0.5319 Erlotinib Erlotinib
CBL 4% COSM41591 p.D460delD Deletion - In frame 0.5319 Erlotinib Erlotinib
CBL 4% COSM41273 p.R830K Substitution - Missense 0.5319 Erlotinib Erlotinib
CBL 4% COSM41269 p.S80N Substitution - Missense 0.5319 Erlotinib Erlotinib
CBL 4% COSM41275 p.W802* Substitution - Missense 0.5319 Erlotinib Erlotinib
CBL 4% COSM41271 p.Q249E Substitution - Missense 0.5319 Erlotinib Erlotinib
PIK3CA 2% COSM29328 p.E545K Substitution - Missense 0.5161 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
PIK3CA 2% COSM29329 p.E542K Substitution - Missense 0.3226 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
PIK3CA 2% COSM29325 p.H1047R Substitution - Missense 0.1613 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
PIK3CA 2% COSM763 p.E545K Substitution - Missense 0.0968 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
PIK3CA 2% COSM30744 p.H1047L Substitution - Missense 0.0968 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
PIK3CA 2% COSM29326 p.H1047Y Substitution - Missense 0.0968 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
PIK3CA 2% COSM775 p.H1047R  Substitution - Missense 0.0645 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
PIK3CA 2% COSM29313 p.M1043I Substitution - Missense 0.0645 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
PIK3CA 2% COSM86997 p.G1049S Substitution - Missense 0.0645 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
PIK3CA 2% COSM760 p.E542K  Substitution - Missense 0.0645 Methotrexate, PAC-1, VX-702 AZD6482, AKTinhibitorVIII, AZD6482, Lapatinib, WZ1-84 
STK11 2% COSM21212 p.E57fs*7  Deletion - Frameshift 0.4435 Metformin, Bryostatin, GW441756 Metformin, Bryostatin, GW441756
STK11 2% COSM21360 p.F354L Substitution - Missense 0.2217 Metformin, Bryostatin, GW441756 Metformin, Bryostatin, GW441756
STK11 2% COSM25854 p.R409W Substitution - Missense 0.2217 Metformin, Bryostatin, GW441756 Metformin, Bryostatin, GW441756
STK11 2% COSM210753 p.D194Y Substitution - Missense 0.2217 Metformin, Bryostatin, GW441756 Metformin, Bryostatin, GW441756
RET 2% COSM1716552 p.E623* Substitution - Nonsense 0.3484 Vandetanib, Vandetanib, Cabozantinib Vandetanib, Vandetanib, Cabozantinib
RET 2% COSM1716551 p.I364fs*? Unknown 0.3484 Vandetanib, Vandetanib, Cabozantinib Vandetanib, Vandetanib, Cabozantinib
RET 2% COSM1716550 p.R67H Substitution - Missense 0.3484 Vandetanib, Vandetanib, Cabozantinib Vandetanib, Vandetanib, Cabozantinib
RET 2% COSM538683 p.R77L Substitution - Missense 0.3484 Vandetanib, Vandetanib, Cabozantinib Vandetanib, Vandetanib, Cabozantinib
RET 2% COSM12992 p.R348R Substitution - coding silent 0.3484 Vandetanib, Vandetanib, Cabozantinib Vandetanib, Vandetanib, Cabozantinib
BRAF 1% COSM1131 p.V600E Substitution - Missense 0.4796 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM476 p.V600E Substitution - Missens 0.2998 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM470 p.L597V Substitution - Missense 0.1199 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM460 p.G469A Substitution - Missense 0.1199 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM460 p.G469A Substitution - Missense 0.06 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM29610 p.G466V Substitution - Missense 0.06 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM34031 p.L485_P490>Y Complex - deletion inframe 0.03 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM36377 p.G466A Substitution - Missense 0.03 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM26457 p.D594N  Substitution - Missense 0.03 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM1155715 p.G469del Deletion - In frame 0.03 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM36245 p.T599_V600insT Insertion - In frame 0.03 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM27329 p.D594G  Substitution - Missense 0.03 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
BRAF 1% COSM1155714 p.G466R Substitution - Missense 0.03 Axitinib, GDC0941, BIBW2992, AZD6482 AZ628+, PLX4720, SB590885, RDEA119, PD-0325901, AZD6244, CI-1040, Nutlin-3a, CHIR-99021, ObatoclaxMesylate, Docetaxel
NRAS 1% COSM584 p.Q61R Substitution - Missense 0.2149 Gefitinib, Imatinib, Lenalidomide, AZD-0530 MitomycinC, AZD6244, OSU-03012, CI-1040
NRAS 1% COSM580 p.Q61K Substitution - Missense 0.2149 Gefitinib, Imatinib, Lenalidomide, AZD-0530 MitomycinC, AZD6244, OSU-03012, CI-1040
NRAS 1% COSM36378 p.Q61L Substitution - Missense 0.1612 Gefitinib, Imatinib, Lenalidomide, AZD-0530 MitomycinC, AZD6244, OSU-03012, CI-1040
NRAS 1% COSM583 p.Q61L  Substitution - Missense 0.2149 Gefitinib, Imatinib, Lenalidomide, AZD-0530 MitomycinC, AZD6244, OSU-03012, CI-1040
NRAS 1% COSM589 p.S65C  Substitution - Missense 0.1075 Gefitinib, Imatinib, Lenalidomide, AZD-0530 MitomycinC, AZD6244, OSU-03012, CI-1040
NRAS 1% COSM585 p.Q61H Substitution - Missense 0.0537 Gefitinib, Imatinib, Lenalidomide, AZD-0530 MitomycinC, AZD6244, OSU-03012, CI-1040
MET 1% COSM249781 p.? Unknown 0.2457 Lapatinib, Erlotinib, Crizotinib Lapatinib, Erlotinib, Crizotinib, Onartuzumab
MET 1% COSM41592 p.L211W Substitution - Missense 0.0819 Lapatinib, Erlotinib, Crizotinib Lapatinib, Erlotinib, Crizotinib, Onartuzumab
MET 1% COSM29311 p.982_1028del47 Deletion - In frame 0.0819 Lapatinib, Erlotinib, Crizotinib Lapatinib, Erlotinib, Crizotinib, Onartuzumab
MET 1% COSM12876 p.S283S Substitution - coding silent 0.0819 Lapatinib, Erlotinib, Crizotinib Lapatinib, Erlotinib, Crizotinib, Onartuzumab
MET 1% COSM29310 p.Q1029_G1105del Deletion - In frame 0.0819 Lapatinib, Erlotinib, Crizotinib Lapatinib, Erlotinib, Crizotinib, Onartuzumab
MET 1% COSM29312 p.982_1028del47 Deletion - In frame 0.0819 Lapatinib, Erlotinib, Crizotinib Lapatinib, Erlotinib, Crizotinib, Onartuzumab
MET 1% COSM144187 p.G983S  Substitution - Missense 0.0819 Lapatinib, Erlotinib, Crizotinib Lapatinib, Erlotinib, Crizotinib, Onartuzumab
MET 1% COSM707 p.T1010I Substitution - Missense 0.0819 Lapatinib, Erlotinib, Crizotinib Lapatinib, Erlotinib, Crizotinib, Onartuzumab
PTEN 1% COSM5154 p.R233* Substitution - Nonsense 0.1619 Bosutinib, OSI-906, Methotrexate, BIBW2992 TGX221, AZD6482, MK-2206, GDC0941
PTEN 1% COSM5776 p.?  Unknown 0.1619 Bosutinib, OSI-906, Methotrexate, BIBW2992 TGX221, AZD6482, MK-2206, GDC0941
PTEN 1% COSM26393 p.R130Q  Substitution - Missense 0.081 Bosutinib, OSI-906, Methotrexate, BIBW2992 TGX221, AZD6482, MK-2206, GDC0941
PTEN 1% COSM5089 p.R173C  Substitution - Missense 0.081 Bosutinib, OSI-906, Methotrexate, BIBW2992 TGX221, AZD6482, MK-2206, GDC0941
PTEN 1% COSM133102 p.R173H Substitution - Missense 0.081 Bosutinib, OSI-906, Methotrexate, BIBW2992 TGX221, AZD6482, MK-2206, GDC0941
PTEN 1% COSM5159 p.Q245* Substitution - Nonsense 0.081 Bosutinib, OSI-906, Methotrexate, BIBW2992 TGX221, AZD6482, MK-2206, GDC0941
PTEN 1% COSM5220 p.G251C Substitution - Missense 0.081 Bosutinib, OSI-906, Methotrexate, BIBW2992 TGX221, AZD6482, MK-2206, GDC0941