Assigned January 26, 2006 for Class February 2, 2006 -
Chapter 1 in Bioinformatics and Drug Discovery edited by Richard S. Larson
Drews, J. 2000. Drug discovery: a historical perspective. Science. 287(5460):1960-4. [Link]
Assigned for class February 9, 2006 -
Chapter 2 in Bioinformatics and Drug Discovery edited by by Richard Larson
Assigned for class February 16, 2006 -
Chapter 3 and 6 in Bioinformatics and Drug Discovery edited by by Richard Larson
Liu, R. et al. 2003. Computationally identifying novel NF-kappaB-regulated immune genes in the human genome. Genome Res. 13:773-780. [Link]
Daborn et al. 2002. A single p450 allele associated with insecticide resistance in Drosophila. Science 297:2253-2256. [Link]
Assigned for class March 9, 2006 (moved to April 13 tentatively) -
Chapter 5 in Modern Methods in Drug Discovery edited by Alexander Hillisch and R.
Assigned in class March 9, 2006 -
Chapter 16 in Chemoinformatics in Drug Discovery edited by Oprea
Chapter 11 in Modern Methods in Drug Discovery by Hillisch and Hilgenfeld
"An Introduction to QSAR Methodology" by A. B. Richon and S. S. Young http://www.netsci.org/Science/Compchem/feature19.html
"QSAR and Drug Design" by D. R. Bevan http://www.netsci.org/Science/Compchem/feature12.html
Assigned in class March 6, 2006 -
Chapter 5 in Modern Methods in Drug Discovery by Hillisch and Hilgenfeld
Additional readings:
Koehn FE and Carter GT. 2005. The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 4(3):206-20. [link]
Gullo VP, McAlpine J, Lam KS, Baker D, and Petersen F. 2006. Drug discovery from natural products. Epub [link]