----------------------------------------------------------------------- BIOINFORMATICS COLLOQUIUM College of Science George Mason University ----------------------------------------------------------------------- Genomic and bioinformatics analyses of human adenoviruses implicated in acute respiratory disease: Insights from the genomes Don Seto, PhD George Mason University Biography: University of California, San Diego. BA Biology The Johns Hopkins University. PhD Biology California Institute of Technology. Postdoc Molecular Biology NIDDK, National Institutes of Health. Senior Staff Fellow DuPont-Merck Pharma. Senior Research Scientist Digital Gene Technologies. Associate Director GeneSys Technology. Director George Mason University. Associate Professor Selected Publications: Vora, G.J., Lin, B., Gratwick, K., Meador, C., Hansen, C., Tibbetts, C., Stenger, D.A., Irvine, M., Seto, D., Purkayastha, A., Freed, N., Gibson, M.L., Russell K.L. and Metzgar, D. (2006). Coinfections of multiple adenoviral species in previously vaccinated patients. Emerging Infectious Diseases 12: 921-930. Lin, B., Wang, Z., Vora, G.J., Thornton, J.A., Schnur, J.M., Thach, D.C., Mueller, K.M., Ligler, A.G., Malanoski, A.P., Santiago, J., Walter, E.A., Agan, B.K., Metzgar, D., Seto, D., Daum, L.T., Kruzelock, R., Rowley, R.K., Hanson, E.H., Tibbetts, C. and Stenger, D.A. (2006). Broad spectrum respiratory tract pathogen identification using re-sequencing DNA microarrays. Genome Res. 16: 527-55. Purkayastha, A., Su, J., McGraw, J., Ditty, S.E., Carlisle, S., Hadfield, T.L., Seto, J., Russell, K.L., Tibbetts, C. and Seto, D. (2005). Genomic and bioinformatics analysis of HAdV-4vac and HAdV -7vac, two human adenovirus (HAdV) strains that constituted original prophylaxis against HAdV-related acute respiratory disease, a reemerging epidemic disease. J Clin Microbiol. 43: 3083-3094. Purkayastha, A., Ditty, S.E., Su, J., McGraw, J., Hadfield, T.L., Tibbetts, C. and Seto, D. (2005). Genomic and bioinformatics analysis of HAdV-4, a human adenovirus that causes acute respiratory disease (ARD). Implications for gene therapy and vaccine vector development. J Virol. 79: 2559-2572. Purkayastha, A., Su, J., Carlisle, S., Tibbetts, C. and Seto, D. (2005). Genomic and bioinformatics analysis of HAdV-7, a human adenovirus of species B1 that causes acute respiratory disease (ARD). Implications for human gene therapy. Virology 332:114 -129. Lauer, K.P., Llorente, I., Blair, E., Seto, J., Krasnov, V., Purkayastha, A., Ditty, S.E., Hadfield, T.L., Buck, C., Tibbetts, C. and Seto, D. (2004). Natural variation among human adenoviruses: Genome sequence and annotation of human adenovirus serotype 1 (HAdV -1). J Gen Virol. 85: 2615-2625. Zafar, N., Mazumder, R. and Seto, D. (2002). CoreGenes: A computational tool for identifying and cataloging "core" genes in a set of small genomes. BMC Bioinformatics 3:12. Mazumder, R., Kolaskar, A. and Seto, D. (2001). GeneOrder: Comparing the order of genes in small genomes. Bioinformatics 17: 162-166. Epidemics Outbreak Surveillance Consortium (as a contributing member- see complete author listing in acknowledgements) Davignon, L., Walter, E., Mueller, K.M., Barrozo, C.P., Stenger, D.A., Lin, B. and Epidemic Outbreak Surveillance Consortium. (2005). Use of resequencing oligonucleotide microarrays for identification of Streptococcus pyogenes and associated antibiotic resistance determinants. J Clin Microbiol. 43: 5690-5695. Peer-reviewed Conference Proceeding Mahadevan, P. and Seto, D. (2006). Comparative genomics using web-based GeneOrder to determine synteny and to function as an annotation tool. BioComp: The 2006 International Conference on Bioinformatics and Computational Biology (Las Vegas, NV. June 26-29, 2006). Book Chapter Kropinski, A.M., Borodovsky, M., Carver, T.J., Cerdeno-Tarraga, A.M., Darling, A., Lomsadze, A., Mahadevan, P., Stothard, P., Seto, D., van Domselaar, G. and Wishart, D.S. (2006). "In silico Identification of Genes in Bacteriophage DNA" in Bacteriophages: Methods and Protocols. M. Clokie and A.M. Kropinski, eds. Humana Press. In press Fall 2006 [05/31/06]. Patent Agan, B.K., Hanson, E.H., Kruzelock, R.P., Lin, B, Rowley, R.K., Seto, D., Stenger, D.A., Thornton, J., Tibbetts, C.J., Thach, D., Vora, G.J., Walter, E.A. and Wang, Z. (2005). Re-sequencing pathogen microarray. United States Patent Office application number 11/177,646. Filed 07/02/05.